OPIOID RECEPTORS AND THEIR LIGANDS: NATURAL AND UNNATURAL
نویسندگان
چکیده
منابع مشابه
Opioid receptors and their ligands.
This review gives a historical perspective, summarizing approximately 25 years of research on opioids. The "typical" opioid peptides produced in the brain, "atypical" opioids encrypted in milk protein or hemoglobin sequences, and extremely potent and selective opioids of amphibian origin are described. The main focus is on the structure-activity relationship studies of peptide ligands for three...
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Metabotropic glutamate receptors (mGluRs) consist of a large family of G-protein coupled receptors that are critical for regulating normal neuronal function in the central nervous system. The wide distribution and diverse physiological roles of various mGluR subtypes make them highly attractive targets for the treatment of a number of neurological and psychiatric disorders. The discovery of ...
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BACKGROUND The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse kappa-opioid receptors. Receptor activation was assessed by measuring the inhibition of cyclic adenosine mono phosphate (cAMP) production stimulated by 5 microM forskolin. Intrinsic activities and pote...
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The therapeutic entities which have been derived from the constituents of opium, the dried exudate of the incised capsule of the opium poppy, have probably spawned more scientific publications than any other drug group. The observations that only the laevorotatory isomer of morphine, the active constituent of opium, was active and that most opioid analgesic drugs had similarities in structure, ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1991
ISSN: 0007-0912
DOI: 10.1093/bja/66.3.370